This will tell you what I worked on during the day today: Hate TurboGears. Hate Pylons. Hate Django. None of them are as good as the Ruby frameworks, in particular because Python ORMs bite the big one. The problem with the Ruby frameworks is Ruby. Which is a large enough problem that I'm going to put up with Python. Or check out Storm, which seems less stone-knives-and-bearskins-ish than the others. Pylons + Routes + Storm might be less objectionable than the other choices.
Oh, Python. Why are your enthusiasts such fans of wheat germ and brewer's yeast for dessert? A little syntactic sugar never hurt anyone.
ETA: The right answer is in fact Pylons + Routes + Elixir.