Jenny Calendar and Arthur Dent
Brian Eno and Soames Forsyte
Rupert Giles and Xander Harris
Sherlock Holmes and Anya Jenkins
Morden and Olivia
Ford Prefect and Spike
Ethan Rayne and Willow Rosenberg
Cmdr Jeffrey Sinclair and Severus Snape
Jon Stewart and Buffy Summers
Joyce Summers and John H. Watson, MD
Lord Peter Wimsey takes a solo flight
Jenny Calendar and Arthur Dent? Well. Um. And that next pair isn't much better: Brian Eno/Soames? I believe Soames has just lifted his nose and sniffed. The third one works out nicely, but really, I didn't need this meme to get them together.
Sherlock and Anya might be very entertaining.